I saw a 50M PL OU go to +6.00 OU from uncontrolled diabetes. I just gave him some +6.00 reading glasses until he got it controlled and went back to PL.
More recently saw a 30M with a +2.00 hyperopic shift in one eye while still 20/20, so I checked his retina and sure enough, big ol' CSR (thankfully not a tumor). Again, I told the patient we're waiting on new glasses to see if it resolves, either without or maybe eventually with treatment.
Oh, and not really a change, but had a kid who was -1.00 OU on A/R but 20/20 sc. So I'm thinking maybe some over-accommodated latent hyperopia. Drop tropicamide, wait 30 minutes, kid is at -0.50 on A/R but still giving weird subjective refractive results, so drop cyclo, wait 30 minutes, and the kid is a +5.00 OU.
Had some other rather large changes with cataracts, maybe +/-5.00 D, but once the cataract is bad enough to do that, I think they've all been sent out for surgery rather than getting new glasses.